is reconstitution solution the same as bacteriostatic water?is reconstitution solution the same as bacteriostatic water?

Due to the potential for toxicity, solutions containing benzyl alcohol should not be used in neonates. RxList does not provide medical advice, diagnosis or treatment. [See USP Controlled Room Temperature. tion ()r-kn (t)-st-t (y)-shn. Both may be used in the injection of peptides, hormones, and various medications, often reconstituted from lyophilized powder. One would be used to control and record temperatures of the cycle as with sterilizers, and the other would be in the cold spot of the chamber. Sample 1 Sample 2 Sample 3. They both are nonpyrogenic meaning they wont cause fever. Lyophilized peptides are considerably stable at room temperature, so if you dont want to reconstitute the lyophilized peptide for some time, dont worry and just keep it a room temperature. Perhaps other adverse effects include fever, abscess formation, thrombosis, tissue death, and infection. Verified Purchase. To answer this question, let's look at an example of Dr. Smith, a pharmaceutical scientist who needs to prepare a peptide solution for a clinical trial. Somatropin should not be used for. The meaning of RECONSTITUTE is to constitute again or anew; especially : to restore to a former condition by adding water. The video I would recommend is embedded below. Do not use unless the solution is clear and seal intact. Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. Last reviewed on RxList: 10/13/2021 The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. The Bacteriostatic Water can be used in diluting drugs that can subsequently be administered by intravenous, . Our goal is to provide you with the most scientifically accurate, unbiased, and comprehensive information regarding all research peptides and SARMs. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. As defined in Section 10.01. Bacteriostatic Water for Injections | The A-Z Guide, Add a header to begin generating the table of contents. In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. Reconstitute Definition & Meaning - Merriam-Webster Muscle + Brawn 2023. Bacteriostatic Water may be used alone or with other medications. This should hopefully shed some light on an easily confusing topic on which water to use. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. Sorry Red, I was ambiguous with my 1st post. Remove Advertising. That being said, using any old water to reconstitute it is a big no-no. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. Patients, athletes, healthcare workers and others use sterile solutions to help in medication delivery, injections, irrigation and other uses. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Penetrate the peptide vial as gently as you can. Both have similar uses and are sterile but have drastically different demographics and indications. Once you have received the verification code, you will be able to choose a new password for your account. 5.0 out of 5 stars Good product. 3) Choose the size of the syringe you want . Reconstitution Solution 4-Pack (30mL) Bactostatic Labs. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic Sodium Chloride: Package Insert - Drugs.com Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic water (BW) has a pH of about 5.7. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. Storing peptides is a very crucial step because a slight fluctuation in the physical conditions can really degrade the peptide vial. Most peptide packages contain mixing instruction. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol . The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. Using in such a matter can cause hemolysis or destruction of red blood cells. 2) Decide how much reconstitution liquid you want to use to convert your lyophilized peptide into an injection-ready solution, and calculate the concentration of the solution. In the There have been times when sterile water has been in short supply. A verification code will be sent to you. A mainstay in medical facilities, research labs, and beyond, bacteriostatic water resists contamination for up to 28 days after initial use. 94-101, 114; 1979. An official website of the United States government, : May contain hydrochloric acid for pH adjustment. To make it easy for you to get the best materials, the Peptides.org team has perused the web and selected the single best online source for your injection material requirements: This trusted vendor has an impressive selection of full research kits for your convenience. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. You cannot simply replace bacteriostatic water with sterile water and vice versa, as they are not the same thing. Sample 1 Sample 2 Sample 3. Bacteriostatic Water for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Because visual guidance is far better to approach, I searched for some of the Youtube videos that could help you in the process. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, . if a dosage is say 20mcg of each individually, wht is a dosage of the mix? Bacteriostatic water vs. sterile water: Reconstitution and PRECAUTIONS sections. Sterile water is labeled for both injections and irrigations whereas bacteriostatic water is only labeled for injections. Vaxxen Labs Reconstitution Solution (30 mL) 2 Pack Specialists generally consider bacteriostatic water to be a more efficient solvent or dilutant. EZCORE INTERNATIONAL PVT. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. While there is not a long-term shortage, an acute shortage is often seen because of either manufacturing facilities malfunction or some medical emergency such as COVID-19. Statements regarding products presented on Peptides.org are the opinions of the individuals making them and are not necessarily the same as those of Peptides.org. (I would personally recommend bacteriostatic water because of its longer shelf-life). Another method of sterilization that has been practiced is the use of gaseous ethylene oxide. As with any ethylene oxide treatment, humidification is necessary. You use AA, wich is a .6% solution of acetic acid. Lets nail the major differences right from the start. How does the math work when reconstituting a peptide with 5mg of two different peptides in the same vial? How to Use HGH: Mixing, Reconstitution, Injecting Step By Step Guide Why is Water Essential to Reconstitution? Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. Before really using the peptide, you will have to add liquid to the powder and MIX it well to make it a solution but it isnt as simple as it sounds! If symptoms appear, injections should be discontinued pending medical consultation [9]. FDA rev date: 6/15/2000. Bacteriostatic Water for Injection Prescribing Information. Some measures are necessary - do not inject the water straight into the powder with force, usually, do not drop or shake a reconstituted vial. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. The preservative agent (0.9% benzyl alcohol) in bacteriostatic water allows packaging in multi-dose vials that resist contamination for up to 28 days when used with sterile needles. Because it is vulnerable to contamination, it is sold in single-dose containers [5]. He is responsible for ensuring the quality of the information presented on our website. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. Do not use unless the solution is clear and seal intact. What Is Bacteriostatic Water For Peptide Reconstitution Recommended dosage guidelines are usually based on either the clinical trials or the efficacy of the peptide. Any transfer and handling, such as loading of the lyophilizer, should take place under primary barriers, such as laminar flow hoods under which the vials were filled. It depends on the compound, there is no universal conversion, About: Muscle and Brawn is a coaching company specializing in bodybuilding, hormones, peptides, anabolics, and other biohacking. Do NOT reuse the same saline syringe to flush VADs before and after medication administration. The pH is 5.7 (4.5 to 7.0). Privacy Policy. Plus, youll feel like a mad scientist, and who doesnt love that feeling? For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? The pH is 5.7 (4.5 to 7.0). Cookie Notice Injections are best suited to fatty areas, such as the thigh or waist. 4 people found this helpful. Archived post. However, some of the other dosage forms that are lyophilized, such as hydrocortisone sodium succinate and methylprednisolone sodium succinate have no antibacterial effect when in solution. Privacy Policy. While there is no fixed dosage of peptides and each peptide accounts for a different dose. Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. To do the reconstitution of PT-141 you will need: Vial of PT-141 Vial of bacteriostatic water (or sterile water) Nothing really. Slowly extract the bacteriostatic water until the solution reaches your desired level. The semi-rigid vial is fabricated from a specially formulated polyolefin. Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Bacteriostatic water (BW) has a pH of about 5.7. How to Properly Reconstitute AOD 9604 + Dose Measurement Lysis is the breaking down of a cell or membrane. Both substances are sterile solvents formulated for use in medical settings. . This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. That means, they are single-dose vials and should be discarded after a single-use. The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. Based on 31 documents. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. The action you just performed triggered the security solution. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. Note that sodium chloride water shouldnt be used as it may result in precipitates. How to use reconstitute in a sentence. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Always double-check which mixture you have because you cannot interchange between these two formulations. 2. : regeneration of an organic form by reorganization of existent tissue without blastema formation. Wipe down all materials with an alcohol swab. Give half a minute for the alcohol to dry so that there is absolutely no risk of bacterial growth. 4,7 For example, daptomycin RF reconstituted in the vial with bacteriostatic water or sterile water and subsequently refrigerated has an in-use storage period of 3 days, and daptomycin RF reconstituted in the vial . Read more. The benzyl alcohol in the water makes bacteriostatic water ideal for diluting any drug that will be administered by intramuscular, intravenous, or subcutaneous injection. The pH is 5.7 (4.5 to 7.0). Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. LTD.Salt Lake Electronics ComplexEP Block, Sector V, BidhannagarKolkata, West Bengal 700091, INDIA. Typical finished product testing that should be reviewed includes dose uniformity testing, sterility testing, and any required stability testing of aged batches of reconstituted solutions. The action you just performed triggered the security solution. If I have a 2mg bottle how much water total do I put into the vial? One vial of BPC 157 contains 5mg, which also means 5000mcg. Bacteriostatic Water for Injection, USP is supplied in a multiple-dose 30 mL plastic fliptop vial (List No. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Bacteriostatic Water for Peptides | Learn How to Prepare Bacteriostatic When diluting or dissolving drugs, mix thoroughly and use promptly. Medications that required diluting with water usually indicate on the bottle which water is preferred for use. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. The container requires no vapor barrier to maintain the proper labeled volume. For intravenous or intramuscular injection, prepare solution by aseptically adding not more than 2 mL of Bacteriostatic Water for Injection or Bacteriostatic Sodium Chloride Injection to the contents of one vial. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. But dont get too excited just yet. As discussed earlier, peptide mixing water is used to dissolve/dilute the lyophilized peptides. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Exogenous formulations are available in powder and liquid forms. Store at 20 to 25C (68 to 77F). In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. [See USP Controlled Room Temperature. Plus, peptide solutions made with bacteriostatic water resist contamination. Do not use unless the solution is clear and seal intact. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Muscle + Brawn is independent and reader-supported. Validation of this handling should also include the use of filled vials of media. Sterile water usually comes in single-unit doses and the reuse of units is prohibited. These include subcutaneous, intramuscular, intravenous, and intradermal injection routes [. But, for long-term storage of the powder form, the required temperature is less than -20 degrees celsius. A major concern with the filling operation is assurance of fill volumes. Wir bieten unseren Kunden mit ntzlichen Informationen und Ratschlge, die sie bentigen, fundierte Entscheidungen zu treffen, ihre Ziele zu erreichen. Obviously, the batching or compounding of these bulk solutions should be controlled in order to prevent any potential increase in microbiological levels that may occur up to the time that the bulk solutions are filtered (sterilized). Two sterile solutions that are commonly used are bacteriostatic water and sterile water. So, if you want to maximize the efficacy of your peptides, follow our guide step-by-step, and soon youll be a reconstitution pro. It is commonly used to reconstitute or dilute therapeutic substances for injection, including intramuscular, intravenous, intradermal, and subcutaneous routes [1, 2]. 11, pp. Bacteriostatic Water for Injections | The A-Z Guide Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Not only is this inefficient, but you may come across low-quality products from inferior manufacturers. By displaying Your Content, you grant Buckle LLC a non-exclusive, worldwide irrevocable, sub licensable license to use, reproduce, adapt, publish, translate and distribute it in any and all media. Before sharing sensitive information, make sure you're on a federal government site. This guide will explore key information on the use of bacteriostatic water for injections. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. Made with Muscle. If you are interested in using bacteriostatic water for injections, look no further! Its preservative content reduces the risk of contamination and infection, boosts shelf life, and enables optimal solvency for aqueous injection [6]. To really know the best solvent in which a peptide will be soluble, you must have to consider some biochemistry knowledge and do some trial and error. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Due to the pH, a more apt solution for fluid replacement is normal saline or dextrose. Contraindications for bacteriostatic water injections include newborn babies and cerebrospinal injections [2, 8]. Here are some general guidelines for storing reconstituted peptides: Short-term storage: If you plan to use the reconstituted peptide within a few days, you can store it at 4C in the dark. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. Bacteriostatic Water is available generically and has the same name. Dont just shoot the water like a spray or something. Sterile water is formulated for irrigation, such as rinsing wounds, unlike bacteriostatic water. ], Hospira, Inc., Lake Forest, IL 60045 USA. You hereby indemnify to the fullest extent Buckle LLC from and against any and/or all liabilities, costs, demands, causes of action, damages and expenses arising in any way related to your breach of any of the provisions of these Terms. This information, including any referenced scientific or clinical research, is made available for educational purposes only. swelling of your face, lips, tongue, or throat, redness, warmth, and pain at the injection site, tenderness or irritation at the injection site. did you ever get an answer? Recent inspections have disclosed potency and sterility problems associated with the manufacture and control of lyophilized products. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. Unused vials can remain viable for years with proper storage [4]. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. PDF SOLU-MEDROL (methylprednisolone sodium succinate) Label - Food and Drug Our content is continually monitored by an internal peer-review process to ensure accuracy. The sterilization of the lyophilizer is one of the most frequently encountered problems. But dont worry, were here to help you navigate this tricky process. Good practice for the compounding of lyophilized products would also include batching in a controlled environment and in sealed tanks, particularly if the solution is to be stored prior to sterilization. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. HGH Mixing Reconstitution 1. 29-31, 48; 1986. The process is simple. It is only used for injections such as intravenous, intramuscular and subcutaneous. According to a recent study, 99.9% of people struggle with this step. They both are USP meaning they have an official monograph or documentation by the United States Pharmacopeia, both are not used for IV solutions. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. The dosage and administration schedule should follow applicable recommendations [18, 19]. In case any of the mentioned side effects are present, it is highly advisable to discontinue the use of bacteriostatic water and consult a doctor.